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Abstract
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease, which mainly affects the diarthrodial joints, affects individuals in the middle age of life (30-40 years), with a predominance in women, in an approximate proportion of 3 or 4: 1. The objective of the study was to determine if there are clinical, epidemiological, and serological differences and / or similarities between Paraguayan men and women with RA. Materials and methods: Retrospective, descriptive study. Patients with a diagnosis of RA were included (ACR 1987 criteria, and since 2011 ACR / EULAR 2010), of both sexes.Follow-up in the Department of Rheumatology of the Hospital de Clínicas of the Faculty of Medical Sciences of the National University of Asunción (UN A) and consulted between March 2015 and May 2017. The qualitative variables were expressed as frequencies and percentages, the quantitative variables as means and standard deviation (SD). For the association study, Chi2 was used for qualitative variables and Student‘s T for quantitative variables. The IBM-SPSS Statistics version 23 program was used. A p <0.05 was considered a significant difference. Results: 177 patients were included with the diagnosis of Rheumatoid Arthritis, 82.5% (146/177) were women (W), with a female (W) / male (M) ratio of 4.7 / 1, with a mean age at onset of symptoms of 44.9 ± 13.5 years and a mean duration of disease of 7.9 ± 0.75 years. They were mostly from Asunción and Gran Asunción. When comparing the clinical, epidemiological and serological characteristics between both groups, we found differences in the presence of extra-articular manifestations, although these were not significant (W: 13% vs M: 27.9%, p: 0.09). On the other hand, in relation to the smoking habit (W: 3.4% vs. M: 12.9% p: 0.03) if they presented significant differences, as well as in the average of FR levels, these being higher in males (W: 324.3 ± 286 vs. M: 798.28 ± 305, p: 0.003), but not in ACPA levels or in the presence of them. Conclusion: In our cohort of patients with established RA we have found mostly clinical and epidemiological similarities between men and women, and some differences.
References
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