Comparación de pacientes con artritis reumatoide de origen Mestizo sudamericano y caucásico europeo
Resumen
Introducción: Se ha descrito la existencia de diferencias en las características clínico biológicas de los pacientes con artritis reumatoide (AR) según su origen étnico. Actualmente no existen estudios que comparen a pacientes con AR mestizos y caucásicos en sus respectivas realidades sanitarias. Objetivos: Comparar las principales características clínico-epidemiológicas y las relacionadas con la actividad de la enfermedad y el grado de discapacidad entre pacientes con AR mestizos sudamericanos y caucásicos europeos. Métodos: Estudio descriptivo, comparativo, transversal. Se incluyeron pacientes con diagnóstico de AR mestizos de Lima, Perú y caucásicos de Barcelona, España. Se evaluaron las diferencias de las variables entre las dos poblaciones mediante el uso de t-test para variables continuas y ji-cuadrado para variables categóricas. Los análisis estadísticos se realizaron mediante el paquete estadístico IBM SPSS Statistics versión19.0. Resultados: Se incluyó a 201 pacientes, 101 de origen caucásico europeo y 100 de origen mestizo. Se objetivó que los mestizos presentaban un mayor tiempo de demora del diagnóstico, FR positivo, limitaciones para uso de terapia biológica, con menor edad y debut más temprano. Al comparar el valor de la media del DAS28 se objetivó que el grupo de pacientes de origen mestizo presentaba un valor significativamente mayor en comparación al grupo de origen caucásico (3,26 ± 1,33 vs 3,86 ± 1,42, p = 0,003). No hubo diferencias significativas en el mHAQ entre ambos grupos (0,41 ± 0,39 vs 0,41 ± 0,54, p = 0,886).Descargas
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