Keywords
ultrasound
How to Cite
Abstract
Introduction: Primary Sjögren‘s Syndrome is anautoimmune disease that is characterized by an inflammatory process that primarily affects the exocrine glands. There is growing interest in the use of salivary gland ultrasound as a non-invasive tool for the diagnosis of primary Sjögren‘s Syndrome (pSS).
Objective: To describe the ultrasound findings of salivary glands and glandular biopsy in patients with suspected primary Sjögren‘s Syndrome.
Materials and methods: A cross-sectional observational study including adult patients with suspected pSS. In all cases, ultrasound and salivary gland biopsy were performed. Epidemiological, clinical, imaging (i.e. ultrasound) variables as well as pathology results of salivary gland biopsies were recorded. A descriptive analysis of the variables was carried out.
Results: 23 patients with suspected pSS were included. The average age of the patients was 47.7±11.1 years, and 96.0% were female. All ultrasounds showed findings compatible with pSS, while 96% of the biopsies reported results compatible with pSS.
Conclusion: In this group of patients, a high percentage of cases showed data compatible with pSS, both in the ultrasound and biopsy of the salivary glands.
References
(1) Witte T. Sjögren-Syndrom [Sjögren‘s syndrome]. Z Rheumatol. 2019;78(6):511-517.
(2) Mariette X, Criswell LA. Primary Sjögren‘s Syndrome. N Engl J Med.2018; 378(10):931-939.
(3) de Paiva CS, Pflugfelder SC. Mechanisms of Disease in Sjögren Syndrome- New Developments and Directions. Int J Mol Sci. 2020;21(2):650.
(4) Lee KA, Choi W, Kim J, Lee SH, Kim HR, Kim HS. Elderly-onset primary Sjögren‘s syndrome focused on clinical and salivary gland ultrasonographic features. Joint Bone Spine. 2021;88(4):105132.
(5) Fernandez-Avila D, Rincon-Ria D, Bernal-Macias S, Gutierrez J, Rosselli D. Prevalencia y características demográficas del síndrome de Sjögren en Colombia. Reumatol Clin.2020;16(4):286–289.
(6) van den Hoogen LL, van Laar JM. Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren‘s syndrome. Best Pract Res Clin Rheumatol. 2020;34(1):101485.
(7) Geng Y, Li B, Deng X, Ji L, Zhang X, Zhang Z. Salivary gland ultra-sound integrated with 2016 ACR/EULAR classification criteria improves the diagnosis of primary Sjögren‘s syndrome. Clin Exp Rheumatol. 2020;38 (2):322-328.
(8) Jousse-Joulin F, Gatineau C. Baldini A. Baer F. Barone H. Bootsma, et al. Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren’s síndrome.
(9) Baer AN, Walitt B. Update on Sjögren Syndrome and Other Causes of Sicca in Older Adults. Rheum Dis Clin North Am. 2018;44(3):419-436.
(10) Pasoto SG, Adriano de Oliveira Martins V, Bonfa E. Sjögren‘s syndrome and systemic lupus erythematosus: links and risks. Open Access Rheumatol. 2019;11:33-45.
(11) Bădărînză M, Serban O, Maghear L, Bocsa C, Micu M, Damian L, Felea I, Fodor D. Shear wave elastography as a new method to identify parotid lymphoma in primary Sjögren Syndrome patients: an observational study. Rheumatol Int. 2020;40(8):1275-1281.
(12) Retamozo S, Brito-Zerón P, Ramos-Casals M. Prognostic markers of lymphoma development in primary Sjögren syndrome. Lupus. 2019;28(8):923- 936.
(13) Hernandez-Molina G, Faz-Munoz D, Astudillo-Angel M, Iturralde-Chavez A, Reyes E. Coexistance of Amyloidosis and Primary Sjögren‘s Syndrome: An Overview. Curr Rheumatol Rev. 2018;14(3):231-238.
(14) Fana V, Dohn UM, Krabbe S, Terslev L. Application of the OMERACT Grey- scale Ultrasound Scoring System for salivary glands in a single-centre cohort of patients with suspected Sjögren‘s syndrome. RMD Open. 2021;7(2):e001516.
(15) Saied F, Włodkowska-Korytkowska M, Maślińska M, Kwiatkowska B, Kunisz W, Smorawińska P, Sudoł-Szopińska I. The usefulness of ultrasound in the diagnostics of Sjögren‘s syndrome. J Ultrason. 2013 Jun;13(53):202-11. doi: https://doi.org/10.15557/JoU.2013.0020.
(16) Martire MV, Santiago ML, Cazenave T, Gutierrez M. Latest Advances in Ultra sound Assessment of Salivary Glands in Sjögren Syndrome. J Clin Rheumatol. 2018 Jun;24(4):218-223. doi: https://doi.org/10.1097RHU.0000000000000625.
(17) Lucchesi D, Pontarini E, Donati V, Mandarano M, Sidoni A, Bartoloni E, et al. The use of digital image analysis in the histological assessment of Sjögren‘s syndrome salivary glands improves inter-rater agreement and facilitates multicentre data harmonisation. Clin Exp Rheumatol. 2020;38 Suppl 126(4):180-188.
(18) Jousse-Joulin S, Gatineau F, Baldini C, Baer A, Barone F, Bootsma H, et al. Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren‘s syndrome. J Intern Med. 2020 Feb;287(2):180-188. doi: https://doi.org/10.1111/joim.12992.
(19) Liao R, Yang HT, Li H, Liu LX, Li K, Li JJ, et al. Recent Advances of Salivary Gland Biopsy in Sjögren‘s Syndrome. Front Med (Lausanne). 2022 Jan 10;8:792593. doi: https://doi.org/10.3389/fmed.2021.792593. PMID: 35083248; PMCID: PMC8784519.