GEN POMP: acerca de su participación en los mecanismos de autoinmunidad e inflamación

Luis Alberto  Aparicio-Vera; Iris Paola  García-Herrera

doi:10.18004/rpr/2024.10.01.30

Luis Alberto Aparicio-Vera Hospital para el Niño Poblano, Departamento de Reumatología Pediátriatrica. Puebla, México https://orcid.org/0000-0002-3034-0415
Iris Paola García-Herrera Hospital para el Niño Poblano, Departamento de Reumatología Pediátriatrica. Puebla, México https://orcid.org/0000-0002-5057-071X

DOI: https://doi.org/10.18004/rpr/2024.10.01.30

Palabras clave: Gene POMP, Proteosoma, Ubiquitina, Autoinmunidad

Resumen

En esta revisión abordamos la autoinmunidad, destacando los mecanismos defectuosos en la tolerancia inmunológica y su relación con enfermedades autoinmunes. Nos centramos en la proteína POMP y el sistema ubiquitina-proteosoma, explicando su función en la degradación proteínica y su papel en la formación del inmunoproteosoma. Se detalla la estructura del proteosoma, la ubiquitinización, y se destaca la influencia de POMP en la respuesta inflamatoria, especialmente en la formación del inmunoproteosoma bajo la estimulación del interferón. Además, se explora la implicación de POMP en procesos autoinflamatorios, como los síndromes asociados al proteosoma, y se menciona su relación con enfermedades autoinmunes, incluyendo el lupus eritematoso sistémico. Se describen casos clínicos que resaltan la importancia de POMP en la autoinmunidad.

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