Clinical Characteristics of Patients with Systemic Lupus Erythematosus Hospitalized at the Hospital Nacional de Itauguá from 2022 to 2024
Abstract
Introduction: Systemic lupus erythematosus (SLE) can lead to complications requiring hospitalization.
Objective: to evaluate the clinical characteristics of patients with SLE admitted to the National Hospital of Itaugua between 2022 and 2024,
Material and Methods: a retrospective observational descriptive study. Ninety-seven clinical records of adult patients diagnosed with SLE, hospitalized in the medical clinic service were reviewed. Sociodemographic variables, comorbidities, reasons for admission, disease activity (SLEDAI), treatment and hospital stay were analyzed. The variables were analyzed by descriptive statistics using Epi Info v7.2 software.
Results: The median age was 30 years, with a predominance of the 18-29 years age group (49.4%) and female sex (84.54%). Respiratory distress was the main reason for hospitalization and arterial hypertension the most common comorbidity. According to the SLEDAI scale, 50.52% presented severe disease activity. Infections were the most frequent complication (55.67%), and 48.5% were hospitalized for less than 10 days. Corticosteroids were the most commonly used drugs (91.75%), followed by immunosuppressants (85.57%).
Conclusion: Most patients presented severe activity and infectious complications, highlighting the need for a comprehensive approach and close follow-up.
Downloads
References
(1) González Jiménez D, Mejía Bonilla S, Cruz Fallas M. Lupus eritematoso sistémico: enfoque general de la enfermedad. Rev Med Sinerg [Internet]. 2021;6(1):e630. doi: https://doi.org/10.31434/rms.v6i1.630
(2) Montiel D, Cacace P. Mortalidad y causas de muerte en pacientes con lupus eritematoso sistémico. Rev Paraguaya Reumatol [Internet]. 2019 Oct 25. Disponible en: http://scielo.iics.una.py/pdf/rpr/v5n2/2413-4341-rpr-5-02-51.pdf
(3) Torres Boggino E, Taboada V, Montiel D, Velázquez G. Factores de riesgo de hospitalización y mortalidad de pacientes internados con lupus eritematoso sistémico en Paraguay. Rev Cienc Salud [Internet]. 2023 Aug 30 [citado 2024 Dec 6];5(1):1-1. Disponible en: https://www.upacifico.edu.py:8043/index.php/PublicacionesUP_Salud/article/view/394
(4) Melgarejo Paniagua PA, Denis Doldán AE, Ferreira Gaona MI, Díaz Reissner CV. Complicaciones en pacientes con lupus eritematoso sistémico. Rev Nac (Itauguá) [Internet]. 2015 Jun [citado 2024 Dec 6];7(1):28-31. Disponible en: https://docs.bvsalud.org/biblioref/2018/05/884809/v7n1a06.pdf
(5) Vásconez González E, López MB, Cuchiparte D, Peláez K, Galarza Maldonado C, Cano Cevallos L, López Cortés A, Ortíz Prado E. Manifestaciones neurológicas del lupus eritematoso sistémico: revisión de literatura. Rev Ecuat Neurol [Internet]. 2021. Disponible en: http://scielo.senescyt.gob.ec/pdf/rneuro/v30n2/2631-2581-rneuro-30-02-00076.pdf
(6) López Posada J. Comportamiento del complemento sérico en pacientes con lupus eritematoso sistémico y enfermedad renal crónica en estadio 5 que se encuentran en hemodiálisis en los centros de cuidado renal de B. Braun Colombia durante el periodo julio 2019 - diciembre 2019 [Internet]. Pereira: Universidad Tecnológica de Pereira; 2021. Disponible en: https://repositorio.utp.edu.co/server/api/core/bitstreams/ed2b021d-139a-4b58-ba80-8e3eb0bf3c6f/content
(7) Ruíz Blasco B. Lupus eritematoso sistémico: revisión bibliográfica [Internet]. Zaragoza: Universidad de Zaragoza; 2022. Disponible en: https://zaguan.unizar.es/record/125699/files/TAZ-TFG-2022-415.pdf
(8) Hernández Gómez P. Atención urgente ante complicaciones del lupus eritematoso sistémico: revisión sistemática [Internet]. Madrid: Universidad Europea; 2023. Disponible en: https://titula.universidadeuropea.com/bitstream/handle/20.500.12880/5355/TFM_Patricia%20Hernandez%20Gomez.pdf?sequence=1&isAllowed=y
(9) Boteanu A. Lupus eritematoso sistémico pediátrico [Internet]. Sociedad Española de Reumatología Pediátrica; 2020. Disponible en: https://www.aeped.es/sites/default/files/documentos/10_lupus.pdf
(10) Oyarzún GM. Access to clinical records for biomedical research purposes. Rev Chil Enferm Respir [Internet]. 2015 Dec [citado 2024 Dec 8];31(4):212-216. doi: http://dx.doi.org/10.4067/S0717-73482015000400006
(11) Dorgham DA, Anwar S, Khaled AS. Infection in systemic lupus erythematosus patients. Egypt Rheumatol [Internet]. 2021 Apr [citado 2025 Mar 27];43(2):115-118. doi: https://doi.org/10.1016/j.ejr.2020.12.007
(12) Selvananda S, Chong YY, Thundyil RJ. Disease activity and damage in hospitalized lupus patients: a Sabah perspective. Lupus [Internet]. 2020 Feb 11. doi: https://doi.org/10.1177/0961203320904155
(13) Manadan AM. Reasons for hospitalization and in-hospital mortality in adult systemic lupus erythematosus [Internet]. 2020 Nov 8. doi: https://doi.org/10.1002/acr2.11195
(14) Dhital R. All-cause hospitalizations and mortality in systemic lupus erythematosus in the US: results from a national inpatient database. Lupus [Internet]. 2019 Nov 26. doi: https://doi.org/10.1007/s00296-019-04484-5
(15) De La Cruz M. Características clínicas y comorbilidades en pacientes con lupus eritematoso sistémico en 2 hospitales de Lambayeque (2017-2022) [Tesis de licenciatura]. Chiclayo: Universidad Católica Santo Toribio de Mogrovejo; 2022. doi: http://hdl.handle.net/20.500.12423/8189
(16) Aragón CC, Ruiz-Ordoñez I, Quintana JH, Suárez-Avellaneda A, Gallego LM, Gallego CN, Bolaños JD, Guerra MA, Ochoa ME, Granados M, Tobón GJ. Clinical characterization, outcomes, and prognosis in patients with systemic lupus erythematosus admitted to the intensive care unit. Lupus [Internet]. 2020 Jun 30. doi: https://doi.org/10.1177/0961203320935176
(17) Pérez-Correa JC, Ariza-Rodríguez DJ, Díaz-Jiménez MC, Fernández-Ávila DG, Gutiérrez JM, Rosselli D. Costo de atención hospitalaria en pacientes con lupus eritematoso sistémico en un hospital de alta complejidad en Colombia. Rev Colomb Reumatol [Internet]. 2024. doi: https://doi.org/10.1016/j.rcreu.2024.06.002
Copyright (c) 2025 Celeste Figueroa, Marcelo Servin, Laura Silviana Aria Zaya, María Eugenia Acosta de Hetter
This work is licensed under a Creative Commons Attribution 4.0 International License.
