Association of vitamin D receptor gene polymorphisms and psoriasis severity
Abstract
Several studies have investigated the relationship between vitamin D and immune-mediated diseases, and more recently, polymorphisms of its receptor (VDR) have been linked to susceptibility to psoriasis and other immune-mediated conditions. This study explored the relationship between VDR polymorphisms and the severity of psoriasis in 50 patients with psoriasis and 50 healthy controls at the Dermatology Department of FCM_UNA from May to November 2018. Three VDR polymorphisms (ApaI, TaqI, and FokI) were analyzed, and vitamin D levels were measured. Although no association was found between the polymorphisms and the severity of psoriasis, an allelic association was identified for the TaqI polymorphism in psoriasis patients. Significant associations were also found between vitamin D deficiency and the TaqI and ApaI polymorphisms. Additionally, a relationship was established between these polymorphisms and psoriasis patients with metabolic syndrome.
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