Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

Palabras clave: Lupus eritematoso sistémico, Autoinmunidad, Anticuerpos, Reumatología, Hidroxicloroquina, Glucocorticoides

Resumen

El Lupus Eritematoso Sistémico (LES) es uno de los prototipos de las enfermedades autoinmunes, compromete principalmente al sexo femenino, con una proporción 9:1 mujer-hombre. Se caracteriza por la formación de autoanticuerpos con la participación de la inmunidad adaptativa e innata, en interacción con los factores genéticos y medioambientales. Estos autoanticuerpos son parte central de la fisiopatología de la enfermedad, causando desde compromiso orgánico leve hasta compromiso multisistémico grave. El diagnóstico es clínico, orientado por una anamnesis detallada, un examen físico exhaustivo y los marcadores de autoinmunidad; eventualmente podría apoyarse en criterios clasificatorios de algunas sociedades científicas. La actual revisión pretende destacar las generalidades sobre la enfermedad, haciendo énfasis en su fisiopatología, presentación clínica, y su abordaje diagnóstico y terapéutico, sirviendo de apoyo para la formación médica integral en beneficio de los pacientes.

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Publicado
2023-09-03
Cómo citar
1.
Sánchez Garcés JP, Ospino Guerra MC, Salas Siado J Ángel, Morales Marenco JJ. Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico. Rev. parag. reumatol. [Internet]. 3 de septiembre de 2023 [citado 23 de mayo de 2024];9(1):25-2. Disponible en: https://revista.spr.org.py/index.php/spr/article/view/175
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